Publications

    2024

    Boulet S, Ursino M, Michelet R, et al. Bayesian framework for multi-source data integration-Application to human extrapolation from preclinical studiesStatistical Methods in Medical Research. 2024;33(4):574-588.


    2022

    Michels, E.H.A., Butler, J.M., Reijnders, T.D.Y. et al. Association between age and the host response in critically ill patients with sepsis. Crit Care 26, 385 (2022)


    Ramirez-Moral, I.; Ferreira, B.L.; Butler, J.M.; van Weeghel, M.; Otto, N.A.; de Vos, A.F.; Yu, X.; de Jong, M.D.; Houtkooper, R.H.; van der Poll, T. HIF-1α Stabilization in Flagellin-Stimulated Human Bronchial Cells Impairs Barrier Function. Cells 2022, 11, 391

    Liselot Dewachter, Julien Dénéréaz, Xue Liu, Vincent de Bakker, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Jan-Willem Veening (2022) Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq eLife 11:e75607.


    2021

    Robin Michelet, Moreno Ursino, Sandrine Boulet, Sebastian Franck, Fiordiligie Casilag, Mara Baldry, Jens Rolff, Madelé van Dyk, Sebastian G. Wicha, Jean-Claude Sirard, Emmanuelle Comets, Sarah Zohar and Charlotte Kloft. The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia. Pharmaceutics 2021, 13, 601. https://doi.org/ 10.3390/pharmaceutics13050601


    Ramirez-Moral I, Yu X, Butler JM, van Weeghel M, Otto NA, Ferreira BL, Maele LV, Sirard JC, de Vos AF, de Jong MD, Houtkooper RH, van der Poll T. mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin. Mucosal Immunol. 2021 Feb 4. doi: 10.1038/s41385-021-00377-8. Epub ahead of print. PMID: 33542495.


    2020

    Liu X, Kimmey JM, Matarazzo L, de Bakker V, Van Maele L, Sirard JC, Nizet V, Veening JW. Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq. Cell Host Microbe. 2021 Jan 13;29(1):107-120.e6. doi: 10.1016/j.chom.2020.10.001. Epub 2020 Oct 28. PMID: 33120116; PMCID: PMC7855995.


    Sorg RA, Gallay C, Van Maele L, Sirard JC, Veening JW. Synthetic gene- regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27608-27619. doi: 10.1073/pnas.1920015117. Epub 2020 Oct 21. PMID: 33087560.

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