Publications

Baldry M, Costa C, Zeroual Y, Cayet D, Pardessus J, Soulard D, Wallet F, Beury D, Hot D, MacLoughlin R, Heuzé-Vourc'h N, Sirard J-C, Carnoy C. Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0086624

Matarazzo L, Costa C, Porte R, Saliou JM, Figeac M, Delahaye F, Bonnefond A, Kloeckner B, Silvin A, Ginhoux F, Faveeuw C, Baldry M, Carnoy C, Sirard JC. Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia. Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00117-X. doi: 10.1016/j.mucimm.2024.11.009. Online ahead of print.PMID: 39592068 Free article.

Sandrine Boulet, Emmanuelle Comets, Antoine Guillon, Linda B.S. Aulin, Robin Michelet, Charlotte Kloft, Sarah Zohar, Moreno Ursino. Straightforward Phase I Dose-Finding Design for Healthy Volunteers Accounting for Surrogate Activity Biomarkers. Statistics in Biopharmaceutical Research 1–10.

Xue Liu, Laurye van Maele, Laura Matarazzo, Daphnée Soulard, Vinicius Alves Duarte da Silva, et al.. A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection. Cell Host & Microbe, 2024, 32 (3), pp.304-314.e8.

Mélanie Mondemé, Yasmine Zeroual , Daphnée Soulard, Benjamin Hennart, Delphine Beury, et al.. Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function. Journal of Leukocyte Biology, 2024, 115(3):463-475

Charlotte Costa, Jean-Claude Sirard, Paddy S Gibson, Jan-Willem Veening, Erida Gjini, Mara Baldry. Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance. The Journal of Infectious Diseases, 2024;, jiae239

Maia AR, Cezard A, Fouquenet D, Vasseur V, Briard B, Sirard J, Si-Tahar M, Hervé V.2024. Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa. Antimicrob Agents Chemother68:e01361-23

van Linge, C.C.A.; Hulme, K.D.; Peters-Sengers, H.; Sirard, J.-C.; Goessens, W.H.F.; de Jong, M.D.; Russell, C.A.; de Vos, A.F.; van der Poll, T. Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells. Int. J. Mol. Sci. 2024, 25, 309

Boulet S, Ursino M, Michelet R, et al. Bayesian framework for multi-source data integration-Application to human extrapolation from preclinical studies. Statistical Methods in Medical Research. 2024;33(4):574-588.

Erik H.A. Michels, Brent Appelman, Justin de Brabander, Rombout B.E. van Amstel, Osoul Chouchane, Christine C. A. van Linge, Alex R. Schuurman, Tom D.Y. Reijnders, Titia A.L. Sulzer, Augustijn M Klarenbeek, Renée A. Douma, Amsterdam UMC COVID-19 biobank study group, Lieuwe D.J. Bos, W. Joost Wiersinga, Hessel Peters-Sengers, Tom van der Poll. Age-related changes in plasma biomarkers and their association with mortality in COVID-19. European Respiratory Journal Jan 2023, 2300011

Michels EHA, Appelman B, de Brabander J, van Amstel RBE, van Linge CCA, Chouchane O, Reijnders TDY, Schuurman AR, Sulzer TAL, Klarenbeek AM, Douma RA, Bos LDJ, Wiersinga WJ, Peters-Sengers H, van der Poll T; Amsterdam UMC COVID-19 Biobank Study Group. Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia. Am J Respir Crit Care Med. 2024 Feb 15;209(4):402-416.

Michels, E.H.A., Butler, J.M., Reijnders, T.D.Y. et al. Association between age and the host response in critically ill patients with sepsis. Crit Care 26, 385 (2022)

Liselot Dewachter, Julien Dénéréaz, Xue Liu, Vincent de Bakker, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Jan-Willem Veening (2022) Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq eLife 11:e75607.

Robin Michelet, Moreno Ursino, Sandrine Boulet, Sebastian Franck, Fiordiligie Casilag, Mara Baldry, Jens Rolff, Madelé van Dyk, Sebastian G. Wicha, Jean-Claude Sirard, Emmanuelle Comets, Sarah Zohar and Charlotte Kloft. The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia. Pharmaceutics 2021, 13, 601. https://doi.org/ 10.3390/pharmaceutics13050601

Ramirez-Moral I, Yu X, Butler JM, van Weeghel M, Otto NA, Ferreira BL, Maele LV, Sirard JC, de Vos AF, de Jong MD, Houtkooper RH, van der Poll T. mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin. Mucosal Immunol. 2021 Feb 4. doi: 10.1038/s41385-021-00377-8. Epub ahead of print. PMID: 33542495.

Liu X, Kimmey JM, Matarazzo L, de Bakker V, Van Maele L, Sirard JC, Nizet V, Veening JW. Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq. Cell Host Microbe. 2021 Jan 13;29(1):107-120.e6. doi: 10.1016/j.chom.2020.10.001. Epub 2020 Oct 28. PMID: 33120116; PMCID: PMC7855995.

Sorg RA, Gallay C, Van Maele L, Sirard JC, Veening JW. Synthetic gene- regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27608-27619. doi: 10.1073/pnas.1920015117. Epub 2020 Oct 21. PMID: 33087560.